Controlled trial of slow-release aminophylline in childhood asthma: are short-term trials valid?

Lactation nurse increases duration of breast feeding

tifen and placebo and prophylaxis of asthma in young children. Br J Dis Chest 1984;78:163-7. 2 Phelan PD, Landau LI, Olinsky A, (eds). Respiratory illness in children. Oxford: Blackwell Scientific Publications, 1982:186. 3 Hambledon G, Weinberger M, Taylor J, et al. Comparison of cromoglycate and theophylline in controlling symptoms of chronic asthma. Lancet 1977;i:381. 4 Ellis PE, Koysooko R, ...

Trial of cromoglycate and slow-release aminophylline in perennial childhood asthma.

Slow-release oral salbutamol and aminophylline in nocturnal asthma: relation of overnight changes in lung function and plasma drug levels.

In a double-blind controlled trial 14 chronic asthmatic patients with regular nocturnal exacerbations took 16 mg slow-release oral salbutamol (two Ventolin spandets), 450 mg slow-release aminophylline (two Phyllocontin Continus tablets), or placebo at midnight. Mean peak expiratory flow rates on waking were significantly higher on the active drugs than on placebo (p < 0.01 for salbutamol; p < 0...

Randomised controlled trial of aminophylline for severe acute asthma.

OBJECTIVES To determine whether children with severe acute asthma treated with large doses of inhaled salbutamol, inhaled ipratropium, and intravenous steroids are conferred any further benefits by the addition of aminophylline given intravenously. STUDY DESIGN Randomised, double blind, placebo controlled trial of 163 children admitted to hospital with asthma who were unresponsive to nebulise...

Ketamine versus aminophylline for acute asthma in children: A randomized, controlled trial

BACKGROUND There is a lack of consensus regarding second-line therapy in children with acute asthma who fail to the standard therapy. Ketamine had bronchodilator property and may be useful in the treatment of acute asthma. OBJECTIVE The objective of this study was to evaluate the efficacy and safety of ketamine as compared to aminophylline in children with acute asthma who respond poorly to t...